Concern for the psychological health of people affected by the COVID-19 pandemic is necessary. Previous studies suggested that self-compassion contributes to life-satisfaction. However, little is known about the mechanism underlying this relation. This study investigated the relationship between self-compassion and life-satisfaction among Chinese self-quarantined residents during the COVID-19 pandemic. Furthermore, we examined the mediating effect of positive coping and the moderating role of gender in this relation. Participants consist of 337 self-quarantined residents (129 men, 208 women) from a community in China, who completed measures of demographic information, Self-Compassion Scale, Satisfaction with Life Scale, and Simplified Coping Style Questionnaire. The results revealed that self-compassion was positively linked with life-satisfaction. Moreover, positive coping partially mediated the relationship between self-compassion and life-satisfaction for males and not females. In the female group, self-compassion was positively linked with positive coping and life-satisfaction; however, positive coping and life-satisfaction were not significantly linked. These findings indicated that intervention focus on self-compassion could increase life-satisfaction in self-quarantined people during the COVID-19, and self-compassion may contribute to life-satisfaction via positive coping only in the male.