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Rossi, Flavia; Girardello, Raquel; Morais, Carlos; Cury, Ana Paula; Martins, Layla Farage; da Silva, Aline Maria; Abdala, Edson; Setubal, João Carlos; da Silva Duarte, Alberto José
Clinics (São Paulo, Brazil), 10/2017, Letnik: 72, Številka: 10Journal Article
We describe an IncX4 pHC891/16mcr plasmid carrying mcr-1 in a colistin-resistant and carbapenem-susceptible E. coli isolate (HC891/16), ST156, which caused a blood infection in a Brazilian patient with gallbladder adenocarcinoma. Strain HC891/16 was subjected to whole genome sequencing using the MiSeq Platform (Illumina, Inc., USA). Assembly was performed using Mira and ABACAS. The isolates showed resistance only to ciprofloxacin, ampicillin and cefoxitin, and whole-genome sequencing revealed the presence of aac(6′)Ib-cr and blaTEM1. Our findings warn of the possible silent dissemination of colistin resistance by carbapenem-susceptible mcr-1 producers, as colistin susceptibility is commonly tested only among carbapenem-resistant isolates.
