This study assesses the performance of the Weather Research and Forecasting (WRF) model to represent the near-surface weather conditions and the precipitable water vapour (PWV) in the Chajnantor plateau, in the north of Chile, from 2007 April to December. The WRF model shows a very good performance forecasting the near-surface temperature and zonal wind component, although it overestimates the 2 m water vapour mixing ratio and underestimates the 10 m meridional wind component. The model represents very well the seasonal, intraseasonal and the diurnal variation of PWV. However, the PWV errors increase after the 12 h of simulation. Errors in the simulations are larger than 1.5 mm only during 10 per cent of the study period, they do not exceed 0.5 mm during 65 per cent of the time and they are below 0.25 mm more than 45 per cent of the time, which emphasizes the good performance of the model to forecast the PWV over the region. The misrepresentation of the near-surface humidity in the region by the WRF model may have a negative impact on the PWV forecasts. Thus, having accurate forecasts of humidity near the surface may result in more accurate PWV forecasts. Overall, results from this, as well as recent studies, supports the use of the WRF model to provide accurate weather forecasts for the region, particularly for the PWV, which can be of great benefit for astronomers in the planning of their scientific operations and observing time.