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Hypomorphic human SEL1L and HRD1 variants uncouple multilayered ER- associated degradation machineryUmphred-Wilson, Katharine; Adoro, Stanley
The Journal of clinical investigation, 01/2024, Letnik: 134, Številka: 2Journal Article
The suppressor of lin-12-like-HMG-CoA reductase degradation 1 (SEL1LHRD1) complex of the endoplasmic reticulum-associated degradation (ERAD) machinery is a key cellular proteostasis pathway. Although previous studies have shown ERAD as promoting the development and maintenance of many cell types in mice, its importance to human physiology remained undetermined. In two articles in this issue of theJCI, Qi and colleagues describe four biallelic hypomorphic SEL1L and HRD1 variants that were associated with neurodevelopment disorders, locomotor dysfunction, impaired immunity, and premature death in patients. These pathogenic SEL1L-HRD1 variants shine a light on the critical importance of ERAD in humans and pave the way for future studies dissecting ERAD mechanisms in specific cell types.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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