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Gao, Wei; Gao, Fang; Yang, Haikuan; Wang, Zongde; Huang, Yaru
Catalysts, 06/2023, Letnik: 13, Številka: 7Journal Article
Pyranoquinolinones synthesized from citral were used for Cu-catalyzed N-arylation with a wide range of arylboric acids. The reaction proceeded well with a broad substrate scope, providing a direct way to access highly functional pyranoquinolinone core structure derivatives in yields of up to 80%. Compared to citral, the compounds we obtained have a much better inhibitory effect on HeLa cervical cancer cells, and compound 3p has an ICsub.50 value of 4.6 μM, lower than cisplatin’s 5.9 μM.
