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Gear, R.W; Bogen, O; Ferrari, L.F; Green, P.G; Levine, J.D
Neuroscience, 01/2014, Letnik: 257Journal Article
Highlights • In male rats, κ-opioids produce analgesia, followed by anti-analgesia. • Low-dose naloxone blocked anti-analgesia but not analgesia. • Nociceptin/orphanin FQ (NOP) antagonists also blocked anti-analgesia. • Selective kappa antagonist nor-BNI did not block nalbuphine-induced anti-analgesia. • Clinically used agonist–antagonists act at NOP receptors to produce anti-analgesia.
