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Price, Amanda J; Fletcher, Adam J; Schaller, Torsten; Elliott, Tom; Lee, KyeongEun; KewalRamani, Vineet N; Chin, Jason W; Towers, Greg J; James, Leo C
PLoS pathogens, 08/2012, Letnik: 8, Številka: 8Journal Article
The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart from the Cyclophilin A-binding loop, CA has no known interfaces with which to interact with cellular cofactors. Here we describe a novel protein-protein interface in the N-terminal domain of HIV-1 CA, determined by X-ray crystallography, which mediates both viral restriction and host cofactor dependence. The interface is highly conserved across lentiviruses and is accessible in the context of a hexameric lattice. Mutation of the interface prevents binding to and restriction by CPSF6-358, a truncated cytosolic form of the RNA processing factor, cleavage and polyadenylation specific factor 6 (CPSF6). Furthermore, mutations that prevent CPSF6 binding also relieve dependence on nuclear entry cofactors TNPO3 and RanBP2. These results suggest that the HIV-1 capsid mediates direct host cofactor interactions to facilitate viral infection.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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