Abstract Deep-Learning-Scheme (DLS) based medical data assessment has been widely employed in recent years due to its improved accuracy. Our goal is to study the performance of the pre-trained DLS on RGB-scale breast-histology images. The implemented idea holds these phases; (i) Data collection, pre-processing and resizing, (ii) Training the DLS with chosen test-pictures, (iii) Testing and validating the performance of the DLS with 5-fold cross-validation. This investigation considered the breast-histology pictures for the study and binary classification is employed to achieve Normal/Cancer class grouping of images. The proposed work compared the classification performance of AlexNet, VGG16 and VGG19.The experimental outcome of this study authenticates that the AlexNet with the Random-Forest (RF) classifier helps to get a higher classification accuracy (>87%) compared to VGG16 and VGG19.