Diabetes mellitus (DM) is a chronic carbohydrate metabolic disorder. Diabetic foot injury is one of the chronic complications of people with diabetes mellitus because it can cause disability and even cause death. Cow blood waste is a waste that can disturb the environment. Components of the chemical elements contained in cow blood include nitrogen, phosphorus, potassium, organic carbon, erythrocytes and leukocytes which function in the body's defense by fighting infections so that cow blood waste is one alternative solution in the treatment of diabetic feet at a price affordable. Ethosome gel is a gel preparation that has the advantage of penetrating into the skin layer faster and significantly increasing the value of transdermal preparation flux. Based on the results of the study, the desired platelets from cow blood were obtained after sampling from the Makassar city slaughterhouse. The platelets obtained were then weighed as much as 0.5 g, 1 g, and 1.5 g to make a gel formula with a carbopol base of 1%. The gel that has been made is then evaluated like a homogeneous and clear gel physical examination. The pH obtained in formulas 1, 2 and 3 is 6.43; 7.00; and 6.80. The formula 1 has a viscosity of 47,342.6 cps and the formula 2 has a viscosity of 45,678.5 cps while formula 3 has viscosity 35,456.7 cps. In the stability test the results obtained were that the preparation did not experience changes in color and odor.