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Tanaka, H; Naito, T; Sato, H; Kawakami, J
Clinical therapeutics, 08/2017, Letnik: 39, Številka: 8Journal Article
Background Tramadol, a synthetic opioid analgesic, is metabolized to highly active O-desmethylate (ODT) by cytochrome P450 (CYP) 2D6 and to lowly active N-desmethylate (NDT) by CYP2B6 and CYP3A4. The aim of this study was to evaluate the influence of CYP2D6 phenotype on the plasma disposition of tramadol and its metabolic...
