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Yamada, Y.; Boskovic, S.; Aoyama, A.; Murakami, T.; Putheti, P.; Smith, R. N.; Ochiai, T.; Nadazdin, O.; Koyama, I.; Boenisch, O.; Najafian, N.; Bhasin, M. K.; Colvin, R. B.; Madsen, J. C.; Strom, T. B.; Sachs, D. H.; Benichou, G.; Cosimi, A. B.; Kawai, T.
American journal of transplantation, February 2012, Letnik: 12, Številka: 2Journal Article
The presence of alloreactive memory T cells is a major barrier for induction of tolerance in primates. In theory, delaying conditioning for tolerance induction until after organ transplantation could further decrease the efficacy of the regimen, since preexisting alloreactive memory T cells might be stimulated by the transplanted organ. Here, we show that such “delayed tolerance” can be induced in nonhuman primates through the mixed chimerism approach, if specific modifications to overcome/avoid donor‐specific memory T‐cell responses are provided. These modifications include adequate depletion of CD8+ memory T cells and timing of donor bone marrow administration to minimize levels of proinflammatory cytokines. Using this modified approach, mixed chimerism was induced successfully in 11 of 13 recipients of previously placed renal allografts and long‐term survival without immunosuppression could be achieved in at least 6 of these 11 animals. The authors report successful development of the conditioning regimen for “delayed tolerance,” in which recipients initially undergo kidney transplantation with conventional immunosuppression and subsequently receive nonmyeloablative conditioning and donor bone marrow transplantation from the original kidney donor.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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