IntroductionWe investigated public interest in shopping and point-of-sales (POS) of JUUL and Puff Bar products in the context of five regulatory, company sales policy and other events of interest that may have influenced the trajectory of these products during 2019–2021.MethodsOutcome variables included relative search volume (RSV) from Google search queries indicative of shopping interest in and aggregate dollar sales from Nielsen POS for JUUL and Puff Bar in the USA from March 2019 to May 2021. Adjusted autoregressive integrated moving average assessed the observed and predicted trends and adjusted linear regression analysis measured the relative rate of change in the outcome variables for each time period of interest.ResultsAfter the Trump administration announced its plans to ban flavoured e-cigarettes and JUUL Labs, Inc.’s decided to suspend the sales of its sweet and fruity flavoured products, JUUL’s shopping interest RSV and sales declined while Puff Bar’s shopping interest RSV peaked, and its sales increased. From the period following FDA’s announcement of its enforcement guidance policy on unauthorised flavoured cartridge-based e-cigarettes until May 2021, JUUL’s shopping interest RSV and sales continued to decline. Puff Bar’s shopping interest RSV increased, and its sales peaked until the House approved the flavoured e-cigarette ban bill. Puff Bar’s sales steeply declined following suspension of its sales in February 2020. The decline, however, slowed after Puff Bar products were relaunched as ‘synthetic nicotine’ e-cigarettes.ConclusionsPuff Bar’s unprecedented peak in the shopping interest and sales of Puff Bar warrants continued surveillance.