The pernatal outcome of 433 deliveries and 643 newborns, conceived following IVF-ET procedure at a Dep. of Obst. And Gyn. Of Clinical Medical Centre Zagreb in the period 2000-2003 is analyzed. The results are compared to the outcome of 20468 other infants born infants in the same period. The 40,19% of IVF-Et pregnancies were multifetal, among them 29,06 with twins, 8,96 with triplets and 2,42% with quadruplets. Among other 20468 deliveries 310 (1,52%) were multifetal, almost exclusvely twins and only 3 pregnancies with triplets. When correlating the IVF-ET pregnacies and newborns to all others it was established: stillbirth 4,41% versus 1,26%; SC 72,46 vs 11,41% ; delivery < 37 weeks 49,85% vs 11,37; infants LBW 40,88% vs 1,42% ; ELBW infants 4,25% vs 1,03%. In singletons following IVF-ET no difference in relation to spontaneus concevid, whereas well-defined differences in mutiple pregnacies between IVF-ET and spontaneus concevide twins were found: FM in IVF-ET was 66,7 ‰ vs 14,5 ‰, ENM 25,0‰ vs 30,0‰; PM 92,0‰ vs 53,0 ‰. In 111 triplets following IVF-ET fetal mortality was 72,0‰, ENM 36,0 ‰, and PM 108,0‰. Gross malformations in the total IVF-ET group were 3,77% vs 1,67% in othere pregnacies. The authors have confirmed the higher risk of IVF-ET pregnacies, that is caused by higher rate of mutiple pregnacies, of newborns < 37 w., infants < 2500 g. The pregnacies following IVF-ET are high risk pregnancies, they claim for special attention and perinatal care.