Abstract Hispanics comprise 17% of the overall US population and 40% of the population in Texas. Approximately 90% of Hispanic Texans are of Mexican descent. This population presents unique challenges in access to health care and utilization of preventive screening. Although the internet has been rapidly integrated into education and outreach strategies for cancer prevention, its potential impact in reducing health disparities among Hispanics has not been evaluated. The few surveys conducted to date among Hispanics have focused on only those individuals who use the internet and were primarily done for marketing purposes. This study was conducted to identify differences between individuals who use internet compared to non-users in a large cohort of Mexican Americans residing in inner city neighborhoods (Houston, TX). Given that technology has evolved so quickly over the past decade, we limited our analyses to 1313 individuals enrolled in the past 2 years. In our population, most of the participants (58%, N=756) reported that they do not use the internet. Using multivariable logistic regression, we constructed the final model in a backwards, stepwise approach to determine factors associated with internet use. Compared to those who reported using the internet, non-users were significantly (P<0.05) more likely to be male, older (mean age 51.4 vs. 41.3 years old), non-English speakers (71.4% vs. 42.0%), and not have private insurance (14% vs. 25%). Notably, 87% of participants that did not use the internet reported that they almost always spoke in Spanish; in contrast, 44% of internet users reported that they almost always spoke in English. Overall, individuals who do not use the internet were more likely to have traits associated with poorer health and higher risk for health disparity. One of the most important findings from this study is that almost 60% of the Hispanics in this population do not use the internet; additionally, among individuals who use the internet, only 61% reported using any form of social media (Facebook, Google+, Twitter, myspace). These results suggest that the use of social media and internet would not be effective methods to reach this population and have an impact in reducing health disparities in an inner city minority population. Citation Format: Sara S. Strom, Yuko Yamamura. Planning for the future: Reaching an inner city Mexican American population. abstract. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr C09. doi:10.1158/1538-7755.DISP13-C09