Abstract Background Minimally invasive esophagectomy (MIE) has been met with increased interest for the surgical treatment of esophageal cancer. One critical obstacle for the implementation of MIE has been the intrathoracic anastomosis. In this study, we describe a technique of Ivor Lewis MIE in prone position and we present the short-term outcomes of this procedure compared to the McKeown MIE. Methods A total of 53 consecutive patients with with an Adenocacinoma of the gastroesophageal junction (GEJ) or the distal esophagus esophageal who had undergone MIE were included in the analysis. The clinical outcomes were analized and compared between the 24 patients treated with thoracoscopic two field Ivor Lewis (IL) MIE with intrathoracic stapled End-to-side anastomosis and 29 patients treated with thoracoscopic three field McKeown (McK) MIE with cervical stapled End-to-side anastomosis. The main outcome was postoperative respiratory complications. The secondary outcomes included the length of the operation, blood transfusion, number of dissected lymph nodes, postoperative morbidities and mortality. Results No statistical difference was found between postoperative respiratory complications (p: 0, 475), operative time (p: 0395), Lymph node retrieved (p: 0864), blood transfusion (p: 0951), ICU stay (p: 0131), oral intake in days (p: 0592), post operative stay (p:0830), anastomotic leakage (p: 0669), overall morbidity (p:0400), mortality (p: 0267). Anastomotic stenosis were more frequent in the McKeown group (p: 0062). Conclusion The intrathoracic stapled end-to-side anastomosis technique seems to be feasible, safe, and easy to perform, associated with a limited postsurgical complication rate and a good functional outcome. Disclosure All authors have declared no conflicts of interest.