E-viri
Recenzirano
-
Nuytemans, Karen; Vasquez, Marina Lipkin; Wang, Liyong; Van Booven, Derek; Griswold, Anthony J.; Rajabli, Farid; Celis, Katrina; Oron, Oded; Hofmann, Natalia; Rolati, Sophie; Garcia-Serje, Catherine; Zhang, Shanshan; Jin, Fulai; Argenziano, Mariana; Grant, Struan F.A.; Chesi, Alessandra; Brown, Christopher D.; Young, Juan I.; Dykxhoorn, Derek M.; Pericak-Vance, Margaret A.; Vance, Jeffery M.
Alzheimer's & dementia, 01/2022, Letnik: 18, Številka: 10Journal Article
We previously demonstrated that in Alzheimer’s disease (AD) patients, European apolipoprotein E ( APOE ) ε 4 carriers express significantly more APOEε 4 in their brains than African AD carriers. We examined single nucleotide polymorphisms near APOE with significant frequency differences between African and European/Japanese APOE ε 4 haplotypes that could contribute to this difference in expression through regulation. Two enhancer massively parallel reporter assay (MPRA) approaches were performed, supplemented with single fragment reporter assays. We used Capture C analyses to support interactions with the APOE promoter. Introns within TOMM40 showed increased enhancer activity in the European/Japanese versus African haplotypes in astrocytes and microglia. This region overlaps with APOE promoter interactions as assessed by Capture C analysis. Single variant analyses pinpoints rs2075650/rs157581, and rs59007384 as functionally different on these haplotypes. Identification of the mechanisms for differential regulatory function for APOE expression between African and European/Japanese haplotypes could lead to therapeutic targets for APOE ε 4 carriers.
Avtor
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.