INTRODUCTION: The prevalence of hospital-acquired Clostridioides difficile infection (CDI) in a healthcare facility is directly correlated with the efficacy of infection prevention practices. Although associations are well documented between CDI incidence and the exposure to antibiotics and acid-reducing medications, to effectively prevent CDI, all risk factors for transmission must be investigated. This study will demonstrate how innovative practice strategies, created by a multidisciplinary CDI Prevention Team, that were introduced and sustained over a 20 month period of time, resulted in dramatic improvements in CDI rates. METHODS: A cohort of 52 patients with a diagnosis of CDI were chosen for the purpose of determining the efficacy of an innovative, multi-disciplinary intervention. The subject lists were obtained from the NHSN reported cases. The study was comprised of three phases: Pre-intervention Period, Transitional Period, and Intervention Period. During the Transitional Period, the innovative, multidisciplinary intervention was introduced, consisting of a series of preventive strategies aimed at eradicating CDI in the patient population and the hospital's physical environment. RESULTS: Of the 52 patients studied with CDI, 23 patients were Community-Onset while 29 patients were Hospital-Acquired. With each study period, CDI HAI's were shown to decrease as the innovative practice strategies were incorporated into practice. In fact, during the Pre-intervention Period, there were 17 HAI's with 9461 patient days resulting in a 1.79 infection rate; the Transitional Period, 6 HAI'S/14,697 patient days resulting in a 0.40 infection rate; and the Intervention Period, 6 HAI's/33,603 patient days resulting in a 0.17 infection rate. In summary, the annual CDI rate decreased by 62% over one year after implementation of multidisciplinary interventions, demonstrating a statistically significant trend of reducing the infection rates ( P value < 0.0001). CONCLUSION: The data analysis identified well-known CDI risk factors that included residing in long-term care institutions, acid suppressive therapy, prior antibiotic use and the management of the patient's environment. The incorporating of a variety of strategies such as: hand washing, isolation precautions, electronic medical record features, diagnostic testing parameters, UV technology, disposable meal trays, cutlery and plates, and managing the patient's environment, could serve as a paradigm for reducing CDI in a Community-based hospital.