Provider: - Institution: - Data provided by Europeana Collections- U ovom doktorskom radu sintetizirani su Cu(II) molekulski kompleksi Cu(1-TsC-N3)2Cl2 i Cu(1-MsC-N3)2Cl2 biološki aktivnih N-sulfonilcitozinskih (C) liganada s tosilom (Ts) i mezilom (Ms) te novi ciklam-TsC konjugati. Mannichova reakcija TsC liganda, paraformaldehida i ciklama u prisutnosti octene kiseline daje C-aminometilirani konjugat u kojem je ciklam vezan preko metilenskog mosta na C5 položaj citozina. Ista reakcija sa zaštićenim ciklamom daje C4 aminometilirani produkt. Pomoću ESI-MS metode provedena je studija stabilnosti i utjecaja biološki važnih metalnih iona (Na+, K+, Ca2+, Mg2+, Zn2+, Cu2+) na ligande, Cu(II) komplekse, te na poliaza makrocikličke konjugate. U interakciji s ligandima i Cu(II) kompleksima alkalijski metali uslijed elektrostatskih interakcija stvaraju klastere, dok je nastanak bis i tris te miješanih kompleksa uočen u interakciji s Ca2+ i Mg2+. Interakcija Zn2+ s ligandima i Cu(II) kompleksima rezultira nastankom monometalnih kompleksa kao i dimetalnih kompleksa zbog afniteta Zn2+ prema atomima kisika i dušika koji u strukturu uključuju molekule vode. Novi poliaza makrociklički konjugati u interakciji s CuCl2 stvaraju molekulske komplekse u kojima je CuCl2 u ciklamskom prstenu, a u interakciji s ZnSO4 nastaju ionski kompleksi u kojima je Zn2+ smješten u ciklamskom prstenu.- Abstract In this doctoral thesis, Cu (II) molecular complexes Cu(1-TsC-N3)2Cl2 and Cu(1-MsC-N3)2Cl2 of biologically active N-sulfonylcytosine ligands (C) with tosyl (Ts) and mesyl (Ms) and new cyclame-TsC conjugates were synthesized. The Mannich reaction of TsC, paraformaldehyde and cyclame in the presence of acetic acid yields C-aminomethylated konjugate in which the cyclame was introduced through a methylene bridge at C5 position of cytosine. The same reaction with protected cyclame gives C4 aminomethylated product. Using ESI-MS method was conducted stability studies and the influence of biologically important metal ions (Na+, K+, Ca2+, Mg2+, Zn2+, Cu2+) to ligands, Cu (II) complexes, and polyaza macrocyclic conjugates. The interaction of ligands and Cu (II) complexes with biologically important metal ions results with formation of various metal complex. Alkali metals Na+ and K+ formed clusters due to the electrostatic inetractions. Bis, tris and mixed ligand complexes were observed upon mixing with Ca2+ or Mg2+ salt. Interaction with Zn2+ sieed monometal Zn2+ complexes and mixed ligand dimetal complexes that includ water molecules in the structures of the complexes because of affinity of Zn2+ for both O and N atoms. Both ions Cu2+ and Zn2+ were located within the cyclamic ring upon their interaction with polyaza macrocyclic conjugates. Newly formed Cu2+complexes were molecular while the ionic complexes were formed with zinc ions.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana