The universe we know is a product of the human mind. In the primordial phenomenological experience, which man has of himself, two phenomenological facts are imposed: the experience of a stable world of objects and the experience of a world of fields of reality. The exercise of reason, which is given to man evolutionarily, leads to ask what are the real causes that produce these two worlds. Likewise, what is the ultimate truth of the universe. Modern science produces a rational (scientific) knowledge that provides the basis to answer those questions. Classical mechanics explains what is and how a macroscopic world of stable objects is produced. Quantum mechanics, what they are and how the fields of reality are produced, to which man accesses from his human psyche. All this leads us to understand that the universe has a holistic ontology (a way of being). Man, already by his primordial self-experience, but also by the results of science, remains open to the knowledge of cosmic holism. The holistic nature of the universe is the key to addressing the questions surrounding its ultimate truth. Holism continues to make possible the atheistic hypothesis of a universe without God. But it is also true that, beyond nineteenth-century reductionism, holism makes the hypothesis of the existence of God much more plausible today. As a suggestion, the article concludes with a reference to the image of God, and the creation of the universe in God, according to the allegorical discourse of Jewish kabbalah.