Menopause is a stage indicating the end of a woman's menstrual cycles. Metabolic disorders induced by changes in female hormones in postmenopausal period negatively affect the quality of life of women. Abnormal lipid metabolism is a common postmenopausal problem, which is often neglected due to its insidious onset, and may lead to obesity, cardiovascular disease, non-alcoholic fatty liver disease and other problems eventually, seriously endangering the health of postmenopausal women. Exercise intervention has proven to be effective in the containment of abnormal lipid metabolism. We reviewed recent advances in postmenopausal changes in E2 and FSH hormones and their influence on lipid metabolism, the effects of different exercise interventions on postmenopausal lipid metabolism abnormalities, and the pathogenesis of lipid metabolism abnormalities caused by postmenopausal hormone changes and the mechanisms of exercise regulation, then summarized that the changes of E2 and FSH hormone levels in perimenopause per