Provider: - Institution: - Data provided by Europeana Collections- Zloćudne tumore karakteriziraju genetske promjene koje se u većini slučajeva mogu otkriti citogenetičkim metodama. Citogenetička istraživanja na velikom broju tumora ukazuju da kariotipske promjene nisu slučajno raspoređene u genomu, te su one često tumor-specifični klonski poremećaji. Patogenetski je najvažnije identificirati tzv. primarne klonske poremećaje koji su najčešće pojedinačni. Cilj ovog rada bio je istražiti citogenetičke karakteristike ponavljajućih poremećaja u malim staničnim populacijama u multiplom mijelomu i malignim limfomima iz svježeg uzorka dobivenog citološkom punkcijom. Citogenetičke karakteristike istražene su konvencionalnom tehnikom oprugavanja kromosoma i tehnikom FISH na razini interfaznih jezgara i/ili mitotskih kromosoma u 43 ispitanika s multiplim mijelomom i u 80 ispitanika s malignim limfomom. Originalni znanstveni doprinos ovog rada sastoji se u boljoj identifikaciji rijetkih kromosomskih abnormalnosti kojima se specifičnije klasificiraju maligni limfomi i multipli mijelomi, čime se doprinosi boljem kliničkom pristupu u uspostavljanju dijagnoze, prognoze i tretmana navedenih tumora.- Malignant tumours are characterised by genetic changes which can, in the majority of cases, be detected using cytogenetic methods. Cytogenetic research of great number of tumours indicate that karyotypic changes are not allocated in the genome by chance, and that they are commonly tumour-specific clone disorders. Pathogenetically, the most important step is to identify so-called primary clone disorders which are, in the majority of cases, single. The object of this thesis was to discover cytogenetic characteristics of reoccurring disorders in small cell populations in the multiple myeloma and malignant lymphoma. Cytogenetic characteristics were detected using conventional technique of striping chromosomes and FISH technique in the level of interphase nucleus and/or miotic chromosomes in 43 cases diagnosed with multiple myeloma and in 80 cases diagnosed with malignant lymphoma. An original scientific contribution in identifying rare chromosome abnormalities which is used for a more specific classification of malignant lymphoma and multiple myeloma is achieved. The research will contribute to a better clinical approach in diagnosis, prognosis and treatment of these tumors.- All metadata published by Europeana are available free of restriction under the Creative Commons CC0 1.0 Universal Public Domain Dedication. However, Europeana requests that you actively acknowledge and give attribution to all metadata sources including Europeana