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Encimske metode za sintezo zdravilnih učinkovin = Enzymatic methods for drug synthesis
Leskovšek, Vesna ; Urleb, Uroš
V članku podajamo pregled nekaterih encimov, ki jih lahko uporabimo kot katalizatorje pri sintezi zdravilnih učinkovin ali njihovih sintonov. Esteraze in lipaze so najpogosteje uporabljani ...biokatalizatorji pri reakcijah hidrolize in esterifikacij. Sintezo peptidne vezi omogočajo proteaze (alfa-himotripsin). Oksidoreduktaze lahko katalizirajo oksidacije ali redukcije spojin. Med zelo specifične encime, ki katalizirajo zelo ozko paleto reakcij, prištevamo aldolaze (biokataliza aldolne kondenzacije) in sintetaze (N-penicilin sintaza katalizira sintezo beta-laktamskega obroča v penicilinski molekuli.
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