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Nuclear Quadrupole Resonance (NQR) [Elektronski vir] : a useful spectroscopic tool in pharmacy for the study of polymorphismTrontelj, Zvonko, 1937-2024 ...Nuclear Quadrupole Resonance (NQR) spectroscopy has been known for 70 years. It is suitable for the study of measured (poly)crystalline chemical compounds containing quadrupole nuclei (nuclei with ... spin I % 1) where the characteristic NQR frequencies represent the fingerprints of these compounds. In several cases, 14N NQR can distinguish between the polymorphic crystalline phases of active pharmaceutical ingredients (APIs). In order to further stimulate 14N NQR studies, we review here several results of API polymorphism studies obtained in Ljubljana laboratories: (a) In sulfanilamide, a clear distinction between three known polymorphs (%, %, %) was demonstrated. (b) In famotidine, the full spectra of all seven different nitrogen positions were measured; two polymorphs were distinguished. (c) In piroxicam, the 14N NQR data helped in confirming the new polymorphic form V. (d) The compaction pressure in the tablet production of paracetamol, which is connected with linewidth change, can be used to distinguish between producers of paracetamol. We established that paracetamol in the tablets of six different manufacturers can be identified by 14N NQR linewidth. (e) Finally, in order to get an extremely sensitive 14N NQR spectrometer, the optical detection of the 14N NQR signal is mentioned.Source: Crystals [Elektronski vir]. - ISSN 2073-4352 (Vol. 10, no. 6, 2020, str. 450-1-450-22)Type of material - e-articlePublish date - 2020Language - englishCOBISS.SI-ID - 17705475
Author
Trontelj, Zvonko, 1937-2024 |
Pirnat, Janez, 1948- |
Jazbinšek, Vojko |
Lužnik, Janko, 1948-2012 |
Srčič, Stanko |
Lavrič, Zoran |
Beguš, Samo |
Apih, Tomaž |
Žagar, Veselko |
Seliger, Janez
Topics
nuclear quadrupole resonance spectroscopy |
14N NQR and relaxation |
drug polymorphism |
crystal polymorphism |
X-ray powder diffraction (XRPD) |
powder mixture quantification |
NQR with optically pumped magnetometer
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Trontelj, Zvonko, 1937-2024 | 00208 |
Pirnat, Janez, 1948- | 02558 |
Jazbinšek, Vojko | 08274 |
Lužnik, Janko, 1948-2012 | 04317 |
Srčič, Stanko | 09031 |
Lavrič, Zoran | 32037 |
Beguš, Samo | 22480 |
Apih, Tomaž | 07518 |
Žagar, Veselko | 07071 |
Seliger, Janez | 01117 |
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