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Synthesis and biological evaluation of new glutamic acid-based inhibitors of MurD ligaseTomašič, Tihomir ...Mur ligases catalyze the biosynthesis of the UDP-MurNAc-pentapeptide precursorof peptidoglycan, an essential polymer of bacterial cell-wall. They constitute attractive targets for the development of ... novel antibacterial agents. Here we report on the synthesis of a series of 2,4-diaminoquinazolines, quinazoline- 2,4(1H,3H)-diones, 5-benzylidenerhodanines and 5-benzylidenethiazolidine-2,4-diones and their inhibitory activities against MurD from Escherichia coli. Compounds (R)-27 and(S)-27 showed inhibitory activity against MurD with IC50 values of 174 and 206 lM, respectively, which makes them promising starting points for optimization.Source: Bioorganic & Medicinal Chemistry Letters. - ISSN 0960-894X (Vol. 19, no. 1, 2009, str. 153-157)Type of material - article, component partPublish date - 2009Language - englishCOBISS.SI-ID - 2485361
source: Bioorganic & Medicinal Chemistry Letters. - ISSN 0960-894X (Vol. 19, no. 1, 2009, str. 153-157)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Tomašič, Tihomir | 28334 |
Zidar, Nace | 28905 |
Škedelj, Veronika, 1983- | 29903 |
Kovač, Andreja, farmacevtka, 1979- | 27782 |
Blanot, Didier | |
Gobec, Stanislav, 1970- | 15284 |
Kikelj, Danijel | 01463 |
Peterlin-Mašič, Lucija | 19317 |
Source: Personal bibliographies
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