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Cathepsin H indirectly regulates morphogenetic protein-4 (BMP-4) in various human cell linesRojnik, Matija ...Background. Cathepsin H is a cysteine protease considered to play a major role in tumor progression, however, its precise function in tumorigenesis is unclear. Cathepsin H was recently proposed to be ... involved in processing of bone morphogenetic protein 4 (BMP-4) in mice. In order to clarify whether cathepsin H also regulates BMP-4 in humans, its impact on BMP-4 expression, processing and degradation was investigated in prostate cancer (PC-3), osteosarcoma (HOS) and pro-monocytic (U937) human cell lines. Materials and methods. BMP-4 expression was founded to be regulated by cathepsin H using PCR array technology and confirmed by real time PCR. Immunoassays including Western blot and confocal microscopy were used to evaluate the influence of cathepsin H on BMP-4 processing. Results. In contrast to HOS, the expression of BMP-4 mRNA in U937 and PC3 cells was significantly decreased by cathepsin H. The different regulation of BMP-4 synthesis could be associated with the absence of the mature 28 kDa cathepsin H form in HOS cells, where only the intermediate 30 kDa form was observed. No co-localization of BMP-4 and cathepsin H was observed in human cell lines and the multistep processing of BMP-4 was not altered in the presence of specific cathepsin H inhibitor. Isolated cathepsin H does not cleave mature recombinant BMP-4, neither with its amino- nor its endopeptidase activity. Conclusions. Our results exclude direct proteolytic processing of BMP-4 by cathepsin H, however, they provide support for its involvement in the regulation of BMP-4 expression.Source: Radiology and oncology. - ISSN 1318-2099 (Vol. 45, no. 4, 2011, str. 259-266, II)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 3157361
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Rojnik, Matija | 31397 |
Jevnikar, Zala | 26497 |
Mirković, Bojana | 29604 |
Janeš, Damjan, 1977- | 28220 |
Zidar, Nace | 28905 |
Kikelj, Danijel | 01463 |
Kos, Janko, 1959- | 04648 |
Source: Personal bibliographies
and: SICRIS
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