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Mehanizmi vstopa nanodelcev v celice in njihov vpliv na dostavljanje učinkovin = Mechanisms of cellular uptake of nanoparticles and their effect on drug deliveryTeskač, Karmen ...Nanodelci (ND) so dostavni nosilni sistemi nanometerskih velikosti. V zadnjih letih so se izkazali kot pomembna novost v sodobni medicini, tako na področju diagnosticiranja kot tudi zdravljenja. Ker ... so mehanizmi privzema ND v celice različni, pot pa je odvisna od njihovih lastnosti, je za doseganje optimalnih učinkov zdravljenja ključnega pomena, da poznamo medsebojne povezave med privzemom in lastnostmi ND. V članku predstavljamo mehanizme prehoda ND v celice in znotrajcelično dogajanje. ND lahko vstopajo v celice po fagocitozni poti ali po nefagocitoznih poteh (z endocitozo, posredovano s klatrini oz. s kaveolini, z makropinocitozo, po drugih endocitoznih poteh). Pot privzema ND vcelice narekuje mesto sproščanja učinkovine, ki se lahko odvija v kislem in zencimi bogatem okolju lizosomov ali pa ga ND obidejo in sprostijo učinkovino v citosolu ali drugem organelu. To lahko dosežemo s skrbno načrtovano izbiro sestavin za ND in ob upoštevanju njihovih fizikalno-kemijskih lastnosti (velikost, oblika, površinske lastnosti). Fagocitoza je pogosto neželen pojav,saj je njen glavni namen odstranitev tujkov iz telesa, zato je tako privzeta učinkovina največkrat izgubljena. Temu se lahko izognemo z izdelavo čim manjših delcev s hidrofilno ovojnico, najuspešnejše pa je, da na površino pripnemo ligande, ki usmerijo privzem po nefagocitozni poti. Vedenje o načinu privzema ND v celice je torej bistvenega pomena za načrtovanje dostave učinkovin na želeno mesto v celicah, kar lahko znatno izboljša stabilnost ND in ohrani biološko aktivnost predvsem zelo občutljivih učinkovinSource: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 81, št. 3, 2012, str. 225-235)Type of material - article, component partPublish date - 2012Language - slovenianCOBISS.SI-ID - 3220849
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source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 81, št. 3, 2012, str. 225-235)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Teskač, Karmen | 28860 |
Kocbek, Petra, farmacevtka | 24402 |
Erdani-Kreft, Mateja | 15873 |
Kristl, Julijana | 09032 |
Source: Personal bibliographies
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