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Inhibition of D-Ala [Elektronski vir] : D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserineBatson, Sarah ...D-cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes: alanine racemase and D-alanine:D-alanine ligase. By a combination of structural, ... chemical and mechanistic studies here we show that the inhibition of D-alanine:D-alanine ligase by the antibiotic D-cycloserine proceeds via a distinct phosphorylated form of the drug. This mechanistic insight reveals a bimodal mechanism of action for a single antibiotic on different enzyme targets and has significance for the design of future inhibitor molecules based on this chemical structure.Source: Nature communications [Elektronski vir]. - ISSN 2041-1723 (Vol. 8, Dec. 2017, str. 1-7)Type of material - e-articlePublish date - 2017Language - englishCOBISS.SI-ID - 4444273
Author
Batson, Sarah |
De Chiara, Cesira |
Majce, Vita |
Lloyd, Adrian J. |
Gobec, Stanislav, 1970- |
Rea, Dean |
Fülöp, Vilmos |
Thoroughgood, Christopher W. |
Simmons, Katie J. |
Dowson, Christopher G. |
Fishwick, Colin W.G. |
de Carvalho, Luiz Pedro S. |
Roper, David I.
Topics
Farmacevtska kemija |
Kemoterapija |
D-cycloserine |
D-alanine ligase |
peptidoglycan biosynthesis enzymes |
nuclear physics |
experimental particle physics |
protons |
Compton scattering
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Batson, Sarah | |
De Chiara, Cesira | |
Majce, Vita | 29341 |
Lloyd, Adrian J. | |
Gobec, Stanislav, 1970- | 15284 |
Rea, Dean | |
Fülöp, Vilmos | |
Thoroughgood, Christopher W. | |
Simmons, Katie J. | |
Dowson, Christopher G. | |
Fishwick, Colin W.G. | |
de Carvalho, Luiz Pedro S. | |
Roper, David I. |
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