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Povezanost polimorfizmov v genih za glutation peroksidazo in glutation disulfid reduktazo s koncentracijo 8-hidroksi-deoksigvanozina v urinu = Correlation between glutathione peroxydase and glutathione-disulfide reductase gene polymorphisms and 8-hydroxydeoxyguanosine urine concentration : magistrski študijski program Laboratorijska biomedicinaVukoja, Jure, farmacevtEndogeni 8-hidroksi-deoksi gvanozin (8-OHdG) nastaja kot posledica reakcije hidroksilnega radikala z deoksigvanozinskimi ostanki, njegova prisotnost pa lahko povzroči transverzijske mutacije GC>TA, ... ki vodijo v polimorfizme ter hitrejše krajšanje telomer. Uporablja se tako kot diagnostični kot prognostični kazalnik stanj, ki so posledica oksidativnega stresa v telesu. Izloča se z urinom, kar omogoča neinvaziven odvzem in merjenje koncentracije pri posamezniku. Glutation-peroksidaze so družina encimov, ki organizem ščitijo pred oksidativnimi poškodbami preko redukcije vodikovega peroksida. Po drugi strani pa encimi glutation-reduktaze, čigar vloga je redukcija oksidirane oblike glutationa - GSSG nazaj v sulfhidrilno obliko - GSH, na ta način posredno delujejo kot obrambni element proti oksidativnemu stresu. Namen magistrskega dela je bil primerjati metodi RFLP in PCR v realnem času ter ugotoviti morebitno povezanost polimorfizmov rs1050450 G.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [J. Vukoja], 2021Language - slovenianCOBISS.SI-ID - 48223747
Author
Vukoja, Jure, farmacevt
Other authors
Marc, Janja |
Prodan Žitnik, Irena
Topics
Oksidativni stres |
8-hidroksi-deoksi gvanozin |
glutation |
glutation-peroksidaza |
glutation-reduktaza |
polimorfizmi
Library/institution |
City | Acronym | For loan | Other holdings |
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Faculty of Pharmacy, Ljubljana | Ljubljana | FFALJ |
reading room 1 cop.
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Shelf entry
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Vukoja, Jure, farmacevt | |
Marc, Janja | 12189 |
Prodan Žitnik, Irena | 22657 |
Source: Personal bibliographies
and: SICRIS
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