Faculty of Pharmacy, Lj. (FFALJ)
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Kromatografsko določanje topnosti in stabilnosti spojin vodnic = Chromatographic determination of solubility and stability of lead compounds : [magistrski študijski program Industrijska farmacija]Šubic, Žiga, kemijski tehnologProces razvoja do ustrezne zdravilne učinkovine z želenimi lastnostmi je finančno in časovno obremenjujoč proces. Raziskovanje v industriji se začne z rešetanjem visoke zmogljivosti, s katerim lahko ... pridemo do spojin vodnic. Spojina vodnica je naravna, polsintezna ali sintezna spojina z ustreznim farmakološkim in biološkim delovanjem. Spojine vodnice so si med seboj podobne, vendar se razlikujejo v strukturi, fizikalno-kemijskih lastnostih, učinkovitosti delovanja, afiniteti do tarče in podobno. V magistrski nalogi smo se osredotočili predvsem na vidika topnosti in metabolizma teh spojin vodnic, ki nam bosta omogočala boljši vpogled v ustreznost sintetizirane spojine kot potencialne zdravilne u inkovine. Preko parametrov topnosti in metabolizma spojin vodnic lahko v grobem sklepamo, ali ima ta spojina potencial in ali je primerna za nadaljnjo optimizacijo. Topnost in metabolizem smo dokazovali z analitsko metodo tekočinske kromatografije visoke ločljivosti z UV-Vis detekcijo. Za dokazovanje topnosti smo uporabili sedemtočkovno umeritveno premico, da smo pokrili čim večje koncentracijsko območje, v katerem bi lahko potrdili natančnost in točnost rezultatov. Pri metabolizmu smo poleg spojine vodnice dnevno izvajali tudi vzporedni test metabolizma testosterona, ki je služil kot kontrola za ustreznost postopka in orodje, s katerim smo lahko vrednotili rezultate metabolne stabilnosti spojin vodnic. Ugotovili smo, da so testirane spojine relativno slabo topne, vendar metabolno stabilne, kar bo omogočalo načrtovanje novih analogov teh spojin z izboljšanimi lastnostmi.Type of material - master's thesis ; adult, seriousPublication and manufacture - Ljubljana : [Ž. Šubic], 2024Language - slovenianCOBISS.SI-ID - 199077891
Author
Šubic, Žiga, kemijski tehnolog
Other authors
Ilaš, Janez
Topics
Tekočinska kromatografija |
Zdravilne učinkovine |
Topnost |
spojina vodnica |
kineti na topnost |
termodinamska topnost |
metabolizem |
HPLC
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Knjižnica mind 0000000543 ŠUBIC ŽIGA Kromato 0000000319 IN: 0018186 Knjižnica mind 543 ŠUBIC ŽIGA Kromato 319 IN: 0018186 |
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Šubic, Žiga, kemijski tehnolog | ![]() |
Ilaš, Janez | 24400 |
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