Faculty of Pharmacy, Lj. (FFALJ)
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Priložnosti in izzivi vezani na novo skupino zdravil (zaviralci PCSK9) za zniževanje holesterola LDL = the PSCK9 inhibitors - a novel therapeutic target for hypercholesterolemia : opportunities and challengesLocatelli, Igor ...Zaviralci PCSK9 predstavljajo novo terapevtsko skupino zdravil za zdravljenje hiperholesterolemije. Najbolj preučevana iz te skupine so monoklonska protitelesa, kot sta evolokumab in alirokumab, ki ... sta poleti 2015 pridobila dovoljenje za promet. Predvidena sta kot dodatna terapija za zniževanje holesterola LDL, kadar pri zdravljenju s statini ne dosežemo ciljnih vrednosti ali pa zdravljenje s statini ni mogoče. Omenjeni učinkovini sta pri bolnikih s primarno hiperholesterolemijo dodatno zmanjšali koncentracije holesterola LDL za približno 50 %. Neposrednih dokazov o vplivu na zmanjšanje pojavnosti srčno-žilnih dogodkov trenutno še ni na voljo. Največja potreba po teh zdravilih se izraža pri bolnikih z največjim tveganjem za srčno-žilne zaplete in pri katerih obstoječa terapija ni dovolj učinkovita. V to skupino spadajo predvsem bolniki z družinsko hiperholesterolemijo in bolniki, ki so že doživeli srčno-žilni zaplet ter imajo še dodatne dejavnike tveganja (npr. sladkorno bolezen) ali pa zdravljenja s statini ne prenašajo in imajo hkrati visoke vrednosti holesterola LDL.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 67, št. 2-3, 2016, str. 151-158)Type of material - article, component partPublish date - 2016Language - slovenianCOBISS.SI-ID - 4081521
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 67, št. 2-3, 2016, str. 151-158)
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Locatelli, Igor | 24399 |
Janžič, Andrej | 32798 |
Marđetko, Nika | 35433 |
Janežič, Ana, 1985- | 35028 |
Detiček, Andreja, farmacevtka | 37547 |
Kos, Mitja, 1973- | 20374 |
Source: Personal bibliographies
and: SICRIS
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