Faculty of Pharmacy, Lj. (FFALJ)
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Impact of cephalosporin restriction on incidence of infections with extended-spectrum betalactamase- producing Klebsiella pneumoniae in an endemic settingNadrah, Kristina ...Decreasing cephalosporin use was described as an effective intervention in decreasing the incidence of infections caused by Klebsiella pneumoniae harbouring extended-spectrum beta-lactamase (ESBLKP). ... Due to sustained increased levels of infections caused by ESBLKP, a multifaceted antibiotic stewardship intervention aimed to decrease cephalosporin use was carried out at a large medical unit of a teaching hospital. All cephalosporins except the first-generation were restricted and could only be prescribed after authorization by an infectious disease physician. The use of cephalosporins decreased significantly after intervention. The effect was most prominent for the third-generation cephalosporins (7.9%1.5 DDD/100 OBD). There was an increase in the consumption of piperacillin/tazobactam, carbapenems and fluoroquinolones. In contrast to our expectations the ESBLKP incidence increased, but the changes were not statistically significant. The intervention was successful in controlling the prescribing of cephalosporins, but had no impact on incidence of ESBLKP infections.Source: Journal of chemotherapy. - ISSN 1120-009X (Vol. 30, iss. 3, May 2018, str. 150-156)Type of material - article, component part ; adult, seriousPublish date - 2018Language - englishCOBISS.SI-ID - 4473969
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Nadrah, Kristina | 23421 |
Pirš, Mateja, 1974- | 31399 |
Kreft, Samo | 15460 |
Müller-Premru, Manica | 12193 |
Beović, Bojana | 08312 |
Source: Personal bibliographies
and: SICRIS
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