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  • Fiziologija ščitnice : vloga Na+/I--simporterja in metabolizem jodida = Thyroid physiology : the role of Na+/I--symporter and iodide metabolism
    Gaberšček, Simona ; Zaletel, Katja ; Hojker, Sergej
    Background. Cloning of rat and human thyroid Na+/I--symporter (transport protein for iodide) has inspired a large number of studies in the field of thyroid physiology. The results of these studies ... have improved our understanding of various known phenomena in thyroid gland, such as the mechanism of 1) autoregulation (plasma concentration of thyroid hormones remaines within normal range regardless of iodide supply, prevailingly by inhibition of thyroid hormones secretion in conditions of iodide excess and byincreased uptake of iodide in conditions of iodide depletion); 2) the Wolff Chaikoff effect (iodide excess inhibits organification by iodinated organic compounds and decreases the synthesis of thyroid hormones; escape from the acute Wolff Chaikoff effect is caused by the decreased uptake of iodide); 3) the regulation of thyroid growth (the normal thyroid growth requires adequate supply of the gland with iodine in the form of iodide while the regulation mechanisms are preserved). Conclusions. The aim of the present article is to present novel findings in the field of thyroid physiology with a special emphasis on the role of Na+/I--symporter and iodide metabolism. The influence of iodide depletion and repletion on the function of normal thyroid gland is also discussed.
    Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 69, št. 4, apr. 2000, str. 261-265)
    Type of material - article, component part
    Publish date - 2000
    Language - slovenian
    COBISS.SI-ID - 11511513

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