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  • Bcl-1 gene rearrangement and cyclin D1 protein expression in mantle cell lymphoma = Prerazporeditev gena bcl-1 in izražanje beljakovine ciklin D1 pri plaščnoceličnem limfonu
    Koković, Ira ...
    Mantle cell lymphoma (MCL) is a small B-cell non-Hodgkin's lymphoma characterised by a spe- cific chromosomal translocation t (11;14)(q13;q32). This genetic abnormality leads to the juxtaposition of ... the bcl-1 locus on chromosome 11q13 with the immunoglobulin heavy chain locus (IgH) on chromosome14q32, thus resulting in deregulation of the bcl-1 gene. In order toimpro- ve differentiation between MCL and other small B-cell non-Hodgkin's lymphomas we intro- duced a two-step seminested PCR method for detection of the t (11;14)(q13;q32). Cyclin D1 protein expression was detected by the immunohistochemistry. We analysed 16 cases of histologically diagnosed MCL. Fourteen of 16 analysed cases (87,5%) were cyclin D1 positive. Bcl-1 gene was rearranged in 4 of 16 MCL cases (25%). All 4 cases were cyclin D1 positive.
    Source: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 39, supl. 5, okt. 2000, str. 25-27)
    Type of material - article, component part
    Publish date - 2000
    Language - english
    COBISS.SI-ID - 12324057

source: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 39, supl. 5, okt. 2000, str. 25-27)

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