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  • Cyclophosphamide metabolites perforate the apical plasma membranes of urothelial cells in rats
    Zupančič, Daša ; Jezernik, Kristijan
    The apical plasma membrane of differentiated superficial urothelial cells is characterised by the presence of asymmetric unit membrane (AUM). Cyclophosphamide (CP) metabolites cause perforation of ... these thickened membranes. In this study, apical plasma membranes were examined after CP injection by electron microscopy. The immediate effect of the CP metabolites was observed as small round holes appearing, first in the asymmetric apical plasma membrane of terminally differentiated superficial cells, and later in the symmetric apical plasma membrane of exposed undifferentiated intermediate and basal cells. Exposed cells which remained undamaged, immediately underwentmaturation of the symmetric apical plasma-membrane. These results indicate that CP metabolites perforate the symmetric and asymmetric membranes of most urothelial cells.
    Source: Cellular & molecular biology letters : an international journal : cellular membranes, cytoskeleton, nuclear architecture, gene expression, biomolecular interactions, biotechnology. - ISSN 1425-8153 (Vol. 7, no. 1, 2002, str. 123-125)
    Type of material - conference contribution
    Publish date - 2002
    Language - english
    COBISS.SI-ID - 15693785

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