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  • Zdravljenje bolnic z revmatično boleznijo v nosečnosti = Treatment strategy of the rheumatic disease during pregnancy
    Praprotnik, Sonja ; Tomšič, Matija, 1959-
    Treatment strategy of the rheumatic disease during pregnancy will vary according to the maternal or fetal compromise expected. Nonsteroidal anti-inflammatory drug treatment of severe inflammatory ... rheumatic symptoms during pregnancy is appropriate, but such treatment should be withdrawn 6-8 weeks before delivery, because of the effects of these agents on the patent ductus aerteriosus and the risk of maternal and/or fetal hemorrhage. Some corticosteroids such as prednisone and prednisolone do not readily cross the placenta and ean be safely used during pregnancy. There is limited informationon the safety of disease-modifying antirheumatic drugs during pregnancy. Sulfasalasine and hydroxychloroquine treatment may be mantained while gold therapy should probably be discontinued. Use of cyclosporin may be an alternative to other therapy in pregnant patients with severe rheumatic disease. Azathioprine can be used when the maternal condition requires a cytotoxic drug during the fist trimester. Cyclophosphamide, leflunomide and metotrexate are contraindicated during pregnancy. Cyclophosphamide may be considered in late pregnancy if the mother has a life-threatening condition.
    Source: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 42, supl. 3, maj 2003, str. 103-108)
    Type of material - conference contribution
    Publish date - 2003
    Language - slovenian
    COBISS.SI-ID - 16359385

source: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 42, supl. 3, maj 2003, str. 103-108)

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