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  • Pomen odlomka C5a pri apoptozi človeških nevtrofilnih granulocitov = C5a modulation of human neutrophil granulocyte apoptosis
    Kotnik, Vladimir
    Apoptosis is a natural way of elimination of cells, which are no longer needed. Mature granulocytes are terminally differentiated and undergo apoptosis permanently. Reduced cell death of granulocytes ... is an important mechanism for cell accumulation in inflammation. Several molecules can induce or prevent apoptosis of granulocytes. The role of CSa, one of the most powerful chemoattractants, which activates granulocytes via C5aR, was investigated. The annexin binding technique discriminating translocation of membrane phosphatidilserine molecules was used to detect early phases of apoptosis. We found a dose dependent modulation of human blood neutrophil granulocytes apoptosis. Low doses of C5a (1 x 10-11 to 1 x 10-9 M) were apoptogenic, but high doses (1 x 10-8 and 1 x 10-7) prevented granulocytes from apoptosis. We speculate that C5a activates C5aR, which is a 7-TMS receptor connected to the system of G-proteins. G-proteins are activators of phosphatidilinositol and responsible for generation of diacylglicerol. These molecules are connected with activation of caspases and these with apoptosis. Activation of CSaR employing C5a is one of the possible pathways for inductionof apoptosis in human granulocytes. High doses of C5a allow neutrophils to live longer because they are needed for the destruction of the pathogen; low doses drive cells to apoptosis, preventing accumulation of destructing cells at the site of a healing lesion.
    Source: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 43, supl. 5, okt. 2004, str. 21-28)
    Type of material - conference contribution
    Publish date - 2004
    Language - english
    COBISS.SI-ID - 18593753

source: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 43, supl. 5, okt. 2004, str. 21-28)

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