National and University Library, Ljubljana (NUK)
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Katalitični antioksidanti kot nove zdravilne učinkovinePerdih, Andrej, farmacevt ; Pečar, SlavkoVeliko bolezenskih stanj je povezanih s prekomernim nastajanjem reaktivnih kisikovih zvrsti (ROS). Z manganovimi spojinami, ki oponaøajo reakcijo dismutacije, ki jo katalizira encim superoksid ... dismutaza (SOD), se odpira moænost nevtralizacije reaktivnosti ROS. Ti katalitioeni antioksidanti, ki so manganove ione vsebujooee uoeinkovine, so mimetiki encima SOD. Razlikujejo se po in vitro selektivnosti odstranjevanja superoksidnega radikala. Najbolj selektivni so makrociklioeni mimetiki SOD, manj selektivni pa saleni in metaloporfirini. Predstavljene uoeinkovine so uoeinkovite pri zdravljenju kardiovaskularnih, nevrodegenerativnih in respiratornih boleznih, pri vnetnih procesih in pri modulaciji boleoeine ter predstavljajo pomemben poskus zaoeetka zdravljenja z uporabo katalitioenih antioksidantovSource: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 57, št. 1, apr. 2006, str. 24-29)Type of material - article, component partPublish date - 2006Language - slovenianCOBISS.SI-ID - 1912945
source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 57, št. 1, apr. 2006, str. 24-29)
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Database name | Field | Year |
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Perdih, Andrej, farmacevt | 25493 |
Pečar, Slavko | 03070 |
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