Novosti in klinična obravnava neonatalne nekonjugirane hiperbilirubinemije = Update on and clinical management of neonatal unconjugated hyperbilirubinemia
Bratanič, Borut, 1947-
Neonatal unconjugated hyperbilirubinemia continues to be one of the most frequent and puzzling problems in neonatology. Ten years ago, the guidelines for management of neonatal unconjugated ...hyperbilirubinemia were changed when the decision levels for therapeutic interventions were elevated. This year, the American Academy of Pediatrics reviewed and updated its guidelines for management of neonatal unconjugated hyperbilrubinemia. This review article describes advances in the field of neonatal unconjugated hyperbilirubinemia. Among diagnostic procedures, measurements of exhaled CO, "free" bilirubin, transcutaneous bilirubin, screening test for evoked auditory brainstem potentials and brain imaging are highlighted. Investigation of bilirubin's neurotoxicity goes on with research on inhibition of protein/peptide phosphorylation, impaired homeostasis of intracellular calcium, effects of bifirubin on cell membranes and apoptosis, and on the role of P-glycoprotein in protection of the brain against bilirubin. Recent advances in therapy are described, including improvement of light sources for phototherapy using lightemitting diodes, and the use of inhibitors of hem oxygenase, bilirubin reductase, photonic analogues, miniature reactors of glucuronosyl transpherase, as well as gene therapy for the Cligler Najjar type 1 genetic syndrome. In the last part of the article, new guidelines for clinical management of jaundiced new-borns are summarised, with special emphasis on new-borns in whom serum bilirubin reaches level of 427 micromol/1. The appendix contains a new decision tree for clinical management of jaundiced new-borns.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi