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  • Homocistein - dejavnik tveganja za srčno-žilne bolezni = Homocysteine - cardiovascular risk factor
    Rogel, Polona, 1976 ; Žemva, Aleš, 1948-
    Homocysteine is an intermediate product of metabolism of methionine. Folic acid, vitamin B12, and vitamin B6 deficiencies inhibit breakdown of homocysteine, and increase homocysteine concetration in ... cells and in the blood. Numerous studies showed relationship between mild hyperhomocysteinemia and cardiovascular disease. Hyperhomocysteinemia is responsible for about 10% of cardiovascular risk. Mild elevations of homocysteine (>12 micro mol/l) are found in 5 to 10% of general population and in 40% of patients with cardiovascular disease. Hyperhomocysteinemia is associated with procoagulant state. Vascular damage is mostly due to oxidative stress caused by hyperhomocysteinemia. Drugs, diseases, and lifestyle have an impact on homocysteine metabolism. Folic acid deficiency is the most common cause of hyperhomocysteinemia. An adequate intake of at least 400 mg of folate per day is difficult to maintain. Diagnosis and treatment of hyperhomocysteinemia is needed in high-risk individuals and in patients with manifested cardiovascular disease. Target level of homocysteine is below 10 micro mol/l. Reduction of homocysteine may prevent up to 25% of cardiovascular events. Supplementation is effective in patients at risk and in those with known cardiovascular disease. The results of ongoing randomized intervention trials must be awaited, before screening for and treatment of hyperhomocysteinemia can be recommended for general popula tion.
    Source: Slovenska kardiologija : znanstveno strokovna revija za področje srčno-žilne medicine. - ISSN 1581-8543 (Letn. 2, št. 1, 2005, str. 56-64)
    Type of material - article, component part
    Publish date - 2005
    Language - slovenian
    COBISS.SI-ID - 19259865

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