Klinična slika in zdravljenje multiple skleroze = Clinical features and treatments of multiple sclerosis
Šega, Saša, dr. med., nevrologinja, 1962- ; Horvat, Alenka, 1967-
Multiple sclerosis is the most common cause of chronic disability in young adults. In more than 50% of these patients, the disease begins between the ages of 20 and 40. Its clinical course can be ...relapsing-remitting, secondary progressive or primary progressive. Because areas of focal demyelination are disseminated throughout the CNS, the symptoms and signs of multiple sclerosis are varied and many. The most common symptoms are paresthesiae, weakness, blurred vision, diplopia, gait and balance disorders, incoordination and bladder symptoms. Treatment of multiple sclerosis can be divided into symptomatic treatments, treatment of relapses, and prevention of disease progression. Symptomatic treatment can relieve spasticity, fatigue, bladder dysfunction, pain, depression, erectile dysfunction, while corticosteroids areused for treating relapses. Immunomodulatory drugs (interferon-(3 and glatiramer acetate) and immunosuppressive drugs (mitoxantrone) are used to reduce the relapse rate and slow down the progression of relapsing-remitting and secondary progressive multiple sclerosis.
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