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Z dokazi podprto zdravljenje covid-19 z zdravili = Evidence based medicine for covid-19 drug treatmentKnez, Lea, 1981- ...V želji po zdravilu za zdravljenje covid-19 se tudi v strokovni javnosti razveselimo vsakega pozitivnega signala učinkovitosti in pozabljamo, da dokaz varnosti in učinkovitosti zdravil zahteva ... potrditev v randomiziranih kliničnih raziskavah. V prispevku opisujemo najbolj odmevna zdravila pri covid-19: remdesivir, lopinavir z ritonavirjem, favipiravir in (hidroksi)klorokin. Izpostavljamo predvsem remdesivir, ki je dostopen v okviru programa sočutne uporabe in ki je v randomizirani klinični raziskavi na 1059 bolnikih pokazal pomembno hitrejše klinično izboljšanje covid-19, brez pomembnih varnostnih signalov. Na drugi strani izpostavljamo pomanjkanje dokazov učinkovitosti (hidroksi)klorokina, ki smo ga začeli množično uporabljati po objavi predobrih izidov zdravljenja pri le 36 bolnikih, novejše velike opazovalne raziskave pa postavljajo celo sum o manj ugodnih izidih zdravljenja. To je le dokaz več, da se lahko le preko kliničnih raziskav, tudi v Sloveniji, premaknemo iz točke, ko ''mislimo'', k temu, da ''vemo'', katera zdravila so varna in učinkovita pri covid-19Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 71, št. 2, 2020, str. 121-132)Type of material - article, component part ; adult, seriousPublish date - 2020Language - slovenianCOBISS.SI-ID - 21007107
Author
Knez, Lea, 1981- |
Tomšič, Tanja, farmacevtka |
Morgan, Tina |
Locatelli, Igor
Topics
COVID-19 |
zdravljenje |
favipiravir |
hidroksiklorokin |
lopinavir/ritonavir |
remdesivir
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 71, št. 2, 2020, str. 121-132)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Knez, Lea, 1981- | 29281 |
Tomšič, Tanja, farmacevtka | ![]() |
Morgan, Tina | 27884 |
Locatelli, Igor | 24399 |
Source: Personal bibliographies
and: SICRIS
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