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Genski polimorfizmi in akutni koronarni sindrom = Gene polymorphism and acute coronary syndromeČerne, Andreja, 1967- ...Background Genetic variants irn factors that modulate inflammation, endothelial function, lipid metabolism and thrombosis could influence individual susceptibility to coronary artery disease. The aim ... of our study wasto investigate the effect of interleukin-6 (IL-6), endothelial nitric oxidesynthase (eNOS), apolipoprotein E (apoE), platelet glycoprotein receptor IIIa (GPllla), tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) gene polymorphisms on risk of developing acute coronary syndrome (ACS) in a group of Slovenian individuals, Methods We examined 180 subjects, 100 patients with ACS as a first clinical manifestation of obstructive coronary artery disease and 80 age- and gender-matched healthy individuals. Polymorphic sites of the IL-6, eNOS, apoE, GPIIIa, t-PA and PAI-1genes were determined by polymerase chain reaction. Results ThelL-6-174C allele (CC+GC genotypes) and the eNOS TT genotype occurred significantly more frequently in ACS patients then in controls (66% vs. 51% and 20% vs, 9% respectively; both p < 0.05. There was no significant difference in the distribution of the eNOS 4a/b, apoE eta2/eta3/eta4, GPIIIa PIA1/PIA2 t-PA I/D and PAI-1 4G/5G genotypes between the two groups. By multivariate regression analysis adjusting for traditional risk predictors, the-174C IL-6 allele conferred a 3.0 fold increased risk for ACS (95% CI 1.2-7.2; p < 0.05 in our study population. Conclusions In the present study, the IL-6-174G/C polymorphism emerged as an independent factor for ACS risk. The eNOS G/T genotype distribution differed significantly between the two groups, but in adjusted analyses its effect was blunted by traditional risk factors. No association between the eNOS 4a/b, apoE eta2/eta3/eta4, GPIIIa PIA1/PIA2, t-PAI/D and PAI-1 4G/5G gene polymorphisms and ACS was established.Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 75, št. 9, sep. 2006, str. 549-554)Type of material - article, component partPublish date - 2006Language - slovenianCOBISS.SI-ID - 21820633
Author
Černe, Andreja, 1967- |
Čerček, Miha |
Kranjec, Igor, 1946- |
Peterlin, Borut, 1963-
Topics
Coronary Disease |
Genetics |
Hyperlipidemia |
Hypertension |
Polymorphism (Genetics) |
Interleukin-6 |
Nitric-Oxide Synthase |
Apolipoproteins E |
Alteplase |
Plasminogen Activator Inhibitor 1 |
Platelet Glycoprotein Gpiib-Iiia Complex |
Polymerase Chain Reaction |
Hiperlipidemija |
Hipertenzija |
Interlevkin-6 |
Koronarna bolezen |
Polimorfizem (genetika) |
Apolipoproteini E |
Dušikov-oksid, sintaza |
Plazminogen aktivator, inhibitor 1 |
Polimerazna, verižna reakcija |
Trombocitni glikoprotein GPIIb-IIIa, kompleks |
genetika |
geni |
genski polimorfizem |
koronarna bolezen |
diagnostika
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source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 75, št. 9, sep. 2006, str. 549-554)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Černe, Andreja, 1967- | 16254 |
Čerček, Miha | 24050 |
Kranjec, Igor, 1946- | 08592 |
Peterlin, Borut, 1963- | 10458 |
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