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The neuronal cell cycle as a mechanism of pathogenesis in Alzheimer's disease = Nevronski celični ciklus kot patogenetski dejavnik pri Alzheimerjevi bolezniCurrais, Antonio ...Differentiated neurons display specific biochemical, physiological and morphological properties that apparently prevent them from further cell division. Nevertheless, expression of cell cycle ... modulators persists after neuronal differentiation and is upregulated under stress conditions, such as trophic factor deprivation, oxidative stress and the presence of DNA damaging agents. This apparent reactivation of the cell cycle has been postulated as a sine qua non for neuronal death in response to those stress conditions, particularly in Alzheimer's disease. However, the physiological and pathogenicimplications of a putative neuronal cell cycle are far from clear. Here, we discuss the notion of the neuronal cell cycle as a mediator of cell death in Alzheimer's disease.Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 77, supl. II, 2008, str. II-13-II-20)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 24288217
Author
Currais, Antonio |
Malik, Bilal |
Hortobágyi, Tibor |
Soriano, Salvador
Topics
Alzheimer's Disease |
Cell Cycle |
Cell Cycle Proteins |
Neurons |
Apoptosis |
Cyclins |
Oxidative Stress |
Dna Damage |
Celični cikel, beljakovine |
Nevroni |
Celični cikel |
Apoptoza |
DNA, pošdkoba |
Ciklini |
Oksidativni stres |
nevrologija |
nevroni |
lastnosti |
celični ciklus |
apoptoza |
Alzheimerjeva bolezen
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source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 77, supl. II, 2008, str. II-13-II-20)
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Currais, Antonio | ![]() |
Malik, Bilal | ![]() |
Hortobágyi, Tibor | ![]() |
Soriano, Salvador | ![]() |
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