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Možni vpliv živega srebra na patogenezo avtizma = Possible influence of mercury on pathogenesis of autismKobal, Alfred BogomirBackground Autism Spectrum Disorder (ASD) is part of a broader spectrum of developmental disorders appearing in early childhood, known as pervasive developmental disorders. Although its etiology is ... not yet known today, genetic, immunological and environmental factors are considered relevant for the development of autism. Among the latter, there is also a mercury poisoningthough opinions regarding its influence are divided. Some results obtained in recent times reject, while other support the hypothesis that ethyl-Hg in thimerosal, which is used in childrenćs vaccines, influences the development of ASD. Some studies that point to metabolic disorders caused by certain amino acids, oxidative stress and immunological disorders in children with ASD are presented. In addition, some basic findings on the retention, toxicokinetics and biological mechanisms of Hg activity that could influence the development of ASD. Conclusions The presented studies support the assumption that in children with specific metabolic disorders caused by amino acids that reduce glutathione content in cells, and immunological disorders, ethyl-Hg in thimerosal may enhance oxidative impairment in astrocytes and neurons, affect immunological response, and disturb the glutaminergic, serotonergic, holinergic and the central dopaminergic activity. In children with increased susceptibility to Hg, thimerosal in vaccines may be a significant factor in the pathogenesis of ASD.Source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 78, št. 1, 2009, str. 37-44)Type of material - article, component partPublish date - 2009Language - slovenianCOBISS.SI-ID - 25410009
Author
Kobal, Alfred Bogomir
Topics
Autism |
Etiology |
Mercury |
Thimerosal |
Adverse Effects |
Oxidative Stress |
Glutathione |
Timerozal |
Živo srebro |
Oksidativni stres |
Glutation |
avtizem |
razvojne motnje |
oksidativni stres |
etiologija |
živo srebro
source: Zdravniški vestnik : glasilo Slovenskega zdravniškega društva = Slovenian medical journal = journal of Slovenian Medical Association. - ISSN 1318-0347 (Letn. 78, št. 1, 2009, str. 37-44)
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Kobal, Alfred Bogomir | 02463 |
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