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Izražanje receptorjev TLR4 v senzoričnih nevronih, ki oživčujejo vneto dlesen, pri podgani = TLR4 expression in sensory neurons innervating inflamed gingiva in the ratVindiš, Bojan ...Background: Sensory neurons regulate different local inflammatory reactions, also periodontitis. Toll-like receptors (TLR) play a key role in the early phase of this response. TLR expression in ... neurons is up-regulated in various pathological conditions. We aimed to determine whether neurons innervating gingiva express TLR4, a receptor recognizing the polysaccharides of Gram-negative bacteria, and whether this expression is influenced by periodontitis. Materials and methods: Adult female Wistar rats were used (n = 10). Sensory neurons innervating gingiva were labelled with a retrograde marker, Fluoro-Gold (FG), applied to the gingiva of the right upper molar. In the experimental group (n = 5), periodontitis was induced by ligatures left inplace for ten days. FGcontaining neurons were identified in histological sections of trigeminal ganglia, and their TLR4 content was evaluated by immunohistochemical methods. Results: TLR4 was expressed in 12% of neurons innnervating intact gingiva (control group) and in 24% of neurons innervating inflamed gingiva (experimental group). In the experimental group, TLR4 expression was increased especially in middle-sized neurons, where it was 3.4 times more frequent than in the control group. Conclusion: Up-regulation of TLR4 expression in smaller sensory neurons projecting into inflamed gingiva suggests that nociceptors may be sensitized in inflammation. In addition, TLR4-mediated activation of neurons could affect the neurogenic mechanisms that regulate periodontitis.Source: Zobozdravstveni vestnik. - ISSN 0044-4928 (Letn. 65, št. 4/5, 2010, str. 92-98)Type of material - article, component partPublish date - 2010Language - slovenianCOBISS.SI-ID - 28152025
Author
Vindiš, Bojan |
Gašperšič, Rok, 1972- |
Cör, Andrej |
Skalerič, Uroš, 1945-2023 |
Kovačič, Uroš, 1975-
Topics
Periodontitis |
Trigeminal Ganglion |
Anatomy And Histology |
Neurons, Afferent |
Immunohistochemistry |
Receptors, Interleukin-1 |
Fluorescent Dyes |
Disease Models, Animal |
Rats, Wistar |
Receptorji, interlevkin-1 |
Parodontitis |
Trigeminusov ganglij |
Imunohistokemija |
Nevroni aferentni |
Podgane, Wistar |
Bolezen, živalski modeli |
Fluorescentna barvila |
parodontalne bolezni |
dlesni |
vnetja |
nevroni |
podgane
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Database name | Field | Year |
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Vindiš, Bojan | ![]() |
Gašperšič, Rok, 1972- | 19210 |
Cör, Andrej | 11308 |
Skalerič, Uroš, 1945-2023 | 03370 |
Kovačič, Uroš, 1975- | 22360 |
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