National and University Library, Ljubljana (NUK)
-
High-fat medium and circadian transcription factors (cryptochrome and clock) contribute to the regulation of cholesterogenic Cyp51 and Hmgcr genes in mouse embryonic fibroblastsFink, Martina ...The aim of our research was to investigate how cholesterol, unsaturated fatty acids and circadian genes affect the expression of cholesterogenic genes, Cyp51 and Hmgcr, in somatic and in embryonic ... fibroblast cell lines. We found that in immortal Hepa1-6 cells cholesterol represses the transcription of Hmgcr and Cyp51 for 80%, while unsaturated fatty acids have different effects: Hmgcr was repressed for 50%, but Cyp51 was unaffected by the presence of linoloeic acid. In embryonic fibroblasts the abundance of cholesterol in the media did not repress the expression of Cyp51 and Hmgcr, while the presence of linoleic acid repressed transcription of both genes for 40%. Mutation of the Clock gene activated the basal transcription of Cyp51 and Hmgcr and also reconstituted the cholesterol feedback loop, that was lacking in the wild type embryonic fibroblasts. Deletion of repressor genes Cry1 and Cry2 resulted in activated transcription of cholesterogenic genes after addition of linoleic acid, while response to cholesterol was unchanged compared to wild type embryonic fibroblasts. Our results indicate that cholesterol, unsaturated fatty acids and the circadian transcription factors participate in the regulation of cholesterogenesis through different molecular mechanisms, presumably using different SREBP transcription factors and their coregulatory proteins.Source: Acta chimica slovenica. - ISSN 1318-0207 (Vol. 55, no. 1, 2008, str. 85-92)Type of material - article, component partPublish date - 2008Language - englishCOBISS.SI-ID - 3900954
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Fink, Martina | 18992 |
Španinger, Klemen, 1981- | 28347 |
Prosenc Zmrzljak, Uršula | 28382 |
Rozman, Damjana, 1960- | 06013 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location:
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi