National and University Library, Ljubljana (NUK)
-
Influence of crystal habit on the dissolution of simvastatin single crystalsBukovec, Polona, 1982- ...In order to achieve better in-vivo performance of the final dosage form comprising a poorly soluble drug the physicochemical properties of the active pharmaceutical ingredient can be altered not only ... by changing the solid state form but also through the conversion of their crystal habits. To elucidate this approach in the case of simvastatin, the dissolution behaviour of large crystals with the same internal structure but expressing different crystal habits was studied using atomic force microscope. The obtained differences in the dissolution were explained through the determination of crystal morphology, its orientation and assignation of the molecular functional groups that were emerging on the surface of the dissolving crystal face. The dissolution rates of the particular crystal faces measured in situ by atomic force microscopy were found to be distinctly higher than others. The dissolution rate of single crystals differed as a consequence of higher incidence of more polar crystal faces in case of rod shaped crystals isolated from more hydrophilic solvent mixture which we have established through a thorough research of the single crystal morphology, orientation and the assignation of specific functional groups for each of evolved crystal faces.Source: Acta chimica slovenica. - ISSN 1318-0207 (Vol. 62, no. 4, 2015, str. 958-966)Type of material - article, component part ; adult, seriousPublish date - 2015Language - englishCOBISS.SI-ID - 4013681
Author
Bukovec, Polona, 1982- |
Meden, Anton |
Smrkolj, Matej |
Vrečer, Franc
Topics
farmacevtske oblike |
simvastatin |
zdravilne učinkovine |
fizikalne lastnosti |
kemijske lastnosti |
kemijske lastnosti |
simvastatin |
crystal habit |
single crystal orientation |
atomic force microscope |
dissolution rate
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Bukovec, Polona, 1982- | 30208 |
Meden, Anton | 08790 |
Smrkolj, Matej | 28772 |
Vrečer, Franc | 08333 |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location:
Naročanje gradiva za izposojo v čitalnice
Naročanje kopij člankov
Urnik dostave gradiva z oznako DS v signaturi