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Nanosuspenzije - aktualni nanotehnološki pristop za izdelavo farmacevtskih oblik s težko topnimi učinkovinami? = Nanosuspensions - an up-to-date nanotechnology-based approach for formulation of dosage forms with poorly soluble drugs?Kocbek, Petra, farmacevtkaTežko topne učinkovine predstavljajo velik izziv v vseh fazah razvoja zdravil, zato so raziskave novih pristopov za povečevanje topnosti in hitrosti raztapljanja še vedno zelo aktualne. Živimo v dobi ... nanotehnologij, zato so v ospredju zlasti različni nanotehnološki pristopi, kot je izdelava nanosuspenzij. To so disperzije delcev učinkovin nanometrskih velikosti v tekočem mediju in predstavljajo nanodostavni sistem, primeren za vse poti vnosa težko topnih učinkovin v organizem. Njihove prednosti, ki so odraz nanometrske velikosti delcev, so večja topnost, večja hitrost raztapljanja in boljša adhezivnost v primerjavi z delci iste učinkovine mikrometrskih velikosti. Posledično so spremenjene biofarmacevtske lastnosti in farmakološki učinek po vnosu v organizem. Ker so najbolj aktualne raziskave nanosuspenzij za peroralno uporabo, v prispevku predstavljamo njihove značilnosti in pretvorbo v bolniku prijazne trdne farmacevtske oblike.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 67, št. 4, 2016, str. 296-302)Type of material - article, component partPublish date - 2016Language - slovenianCOBISS.SI-ID - 4102769
source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 67, št. 4, 2016, str. 296-302)
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Kocbek, Petra, farmacevtka | 24402 |
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