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Beta - trefoil protease inhibitors unique to higher fungi [Elektronski vir]Sabotič, Jerica ; Renko, Miha, 1980- ; Kos, Janko, 1959-The cysteine protease inhibitors, clitocypin and macrocypins, from higher fungi (mycocypins), together with the serine protease inhibitors highly specific for trypsin cospin and cnispin from higher ... fungi (mycospins), display several characteristics that distinguish them from protease inhibitors from other sources. Their high genetic heterogeneity affects their functionality and/or stability and results in numerous protein variants with slightly different inhibitory profiles that influence the type of protease inhibited and/or the strength of inhibition. They possess the %-trefoil fold that shows high plasticity in their utilization of the 11 diverse loops for the inhibition of various families of proteases through different mechanisms of inhibition. Their high versatility is also seen in their regulatory and defence functions and in their potential applications in biotechnology, crop protection and medicine.Source: Acta chimica slovenica [Elektronski vir]. - ISSN 1580-3155 (Vol. 66, no. 1, 2019, str. 28-36)Type of material - e-articlePublish date - 2019Language - englishCOBISS.SI-ID - 4700785
Author
Sabotič, Jerica |
Renko, Miha, 1980- |
Kos, Janko, 1959-
Topics
inhibitorji proteaz |
makrocipini |
inhibicije |
specifičnost |
obrambna funkcija
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Sabotič, Jerica | 23576 |
Renko, Miha, 1980- | 25629 |
Kos, Janko, 1959- | 04648 |
Source: Personal bibliographies
and: SICRIS
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