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Interlevkini, povezani s Th17, in parametri, povezanimi z dušikovim oksidom pri astmi otrok = Th17-related interleukins and parameters of oxidative/nitrosative events in childhood asthmaFabian, Elisabeth ...Namen: Alergična astma je kronična pljučna bolezen s pomembno vnetno komponento, vključno z reaktivnimi spojinami kisika in dušika. Namen raziskave je bil raziskati odnos s Th17 povezanimi ... interlevkini (IL-6 in IL-10) in markerji vnetja, povezanimi z dušikovim oksidom pri otroški atopični astmi. Metode: V raziskavo je bilo zajetih 35 otrok z astmo (AG) in 21 zdravih otrok (CG); z NIOX monitornim sistemom za dušikov oksid smo izmerili volumen frakcioniranega izdihanega dušikovega oksida (FENO). Nivo IL-6 in IL-10 v plazmi je bil analiziran z ELISA, malondialdehid (MDA) s HPLC. Rezultati: V primerjavi s kontrolno skupino so astmatiki izdihali pomembno večjo količino FENO (p < 0,001) in imeli pomembno višje vrednosti IL-6 (p = 0,012). Pomembna korelacija je bila med aktivatorjem Th17, ki ga predstavlja IL-6, in FENO pri astmatikih, ne pa tudi pri kontrolni skupini. Plazemska koncentracija IL-10 je bila pomembno nižja pri astmatikih (p = 0,002) v primerjavi s kontrolno skupino. V obeh skupinah smo ugotovili statistično pomembno negativno korelacijo med IL-10 in FENO (AG: p = 0,020; CG: p = 0,008). Plazemske vrednosti MDA, ki je lipidni produkt peroksidacije in indikator oksidativnega stresa, so bile pri astmatikih pomembno zvišane (p < 0,001). Pri obeh skupinah je bila pomembna korelacija med MDA in IL-6, ne pa zIL-10. Zaključek: Raziskava je potrdila pomembno povezanost s Th17 povezanimi citokini IL-6 in IL-10, vnetjem pljuč in sistemskim oksidativnim stresom pri otrocih z astmo. Mehanizmi, ki so vpleteni v te procese, še niso popolnoma razjasnjeni. Spremenjeno redoks ravnovesje ima najverjetneje pomemben vpliv na imunopatologijo astme.Source: Acta medico-biotechnica : AMB. - ISSN 1855-5640 (Vol. 4, [no.] 2, 2011, str. 24-33)Type of material - article, component part ; adult, seriousPublish date - 2011Language - englishCOBISS.SI-ID - 512159032
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Fabian, Elisabeth | ![]() |
Pölöskey, Peter | ![]() |
Kósa, Lajos | ![]() |
Elmadfa, Ibrahim | ![]() |
Réthy, Lajos Attila | ![]() |
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